This brief is based on the notion that college is possible not only for students who attend excellent primary and secondary schools but also those who struggle in under-­‐performing public schools. Using the Harlem Children’s Zone® (HCZ®) as a case study, it explores the theory and practice behind this approach; summarizes results, challenges, lessons learned, and recommendations for other communities interested in this approach; and offers examples of three students whose lives changed because of HCZ’s student support strategy. This brief is part of a series, Building the Pipeline: Effective Practice Briefs, which provides guidance on aspects of Promise Neighborhoods.